Dengvaxia Drug Interactions

Concomitant administration: Dengvaxia must not be mixed with any other injectable vaccine(s) or medicinal product(s).
Separate syringes and needles, separate injection sites and preferably separate limbs must be used if any other vaccine(s) or medicinal product(s) is/are concomitantly administered.
Dengvaxia has been evaluated in one clinical study on concomitant administration with Tdap (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) (688 subjects, 9 through 60 years of age), and in two clinical studies with two HPV vaccines (Human Papillomavirus Vaccine, Recombinant) (528 subjects, 9 through 13 years of age and 480 subjects, 9 through 14 years of age).
There was no evidence of an increased rate of reactogenicity or change in the safety profile of the vaccines when Tdap and HPV vaccines were administered concomitantly with Dengvaxia in any of these studies. Antibody responses to Dengvaxia and Tdap vaccine or HPV vaccine components were not negatively affected by concomitant administration.
For patients receiving treatment with immunoglobulins or blood products containing immunoglobulins, such as blood or plasma, it is advisable to wait for at least 6 weeks, and preferably for 3 months, following the end of treatment before administering Dengvaxia, in order to avoid neutralization of the attenuated viruses contained in the vaccine.
For immunosuppressive therapy or corticosteroid therapy, see Contraindications and Precautions.
Vaccine-food interactions: No studies have been performed on interactions between food and Dengvaxia.