History of CV disease including cardiac failure; 1st-degree heart block; resp & cardiac reactions; mild/moderate COPD. Severe peripheral circulatory disturbance/disorders. Masking of hypoglycemic symptoms in DM patients. Masking of clinical signs of hyperthyroidism (eg, tachycardia). Surgical anesth. Severe renal impairment (CrCl <30 mL/min) & hepatic impairment. History of atopy or severe anaphylactic reaction to a variety of allergens. Acute angle-closure glaucoma. Discontinue if signs of serious reactions/hypersensitivity occurs. Low endothelial cell counts. Remove soft contact lenses prior to administration; reinsert after 15 min. Pregnancy & lactation. Childn.