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Aromatt-1

Aromatt-1

anastrozole

Manufacturer:

Hetero Labs

Distributor:

Medicell Pharma
Concise Prescribing Info
Contents
Anastrozole
Indications/Uses
Advanced breast cancer in postmenopausal women w/ hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer.
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Dosage/Direction for Use
Adult including elderly 1 tab once daily.
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Overdosage
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Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Co-administration w/ oestrogen-containing therapies. Concurrent tamoxifen therapy. Severe renal impairment (CrCl <20 mL/min). Moderate or severe hepatic disease. Pregnancy & lactation. Premenopausal women.
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Special Precautions
Biochemically define menopausal status if in doubt. Increased risk of fractures. Assess bone mineral density in women w/ osteoporosis or at risk of osteoporosis prior to & at regular intervals thereafter. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be used w/ LHRH analogues. Not recommended in childn.
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Adverse Reactions
Hot flushes; asthenia; arthralgia, arthritis; headache; nausea; rash. Vag dryness/bleeding; alopecia, allergic reactions; diarrhoea, vomiting; somnolence, carpal tunnel syndrome, sensory disturbances; increased alkaline phosphatase, alanine aminotransferase & aspartate aminotransferase; anorexia, hypercholesterolaemia, bone pain, myalgia.
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Drug Interactions
Reduced plasma conc w/ tamoxifen. Diminished pharmacological action by oestrogen-containing therapies.
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Storage
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Description
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Action
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MIMS Class
Cancer Hormone Therapy
ATC Classification
L02BG03 - anastrozole ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Aromatt-1 tab 1 mg
Packing/Price
30's
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