Switching from SSRIs, antidepressants or antiobsessional drugs. Activation of mania/hypomania. Avoid in patients w/ unstable epilepsy; carefully monitor patients w/ controlled epilepsy. Discontinue use in patients who develop seizures. May cause sexual dysfunction symptoms. Possibility of suicide attempt is inherent in depression & may persist until significant remission occurs; closely supervise patients during the early course of therapy. Observe same precautions when treating patients w/ depression, OCD, panic disorder or PTSD. Hepatic impairment. May impair mental or physical abilities required for the performance of potentially hazardous tasks (eg, driving a car or operating machinery). Women of childbearing potential should employ an adequate contraception method. Pregnancy & lactation.
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