Apo-Quetiapine Overdosage

In clinical trials, survival has been reported in acute overdoses of up to 30 grams of quetiapine. Most patients who overdosed reported no adverse events or recovered fully from the reported events. Death has been reported in a clinical trial following an overdose of 13.6 grams of quetiapine alone.
In postmarketing experience, there have been very rare reports of overdose of quetiapine alone resulting in death or coma.
Patients with pre-existing severe cardiovascular disease may be at an increased risk of the effects of overdose. (See Precautions.)
In general, reported signs and symptoms were those resulting from an exaggeration of the drug's known pharmacological effects, ie, drowsiness and sedation, tachycardia and hypotension.
There is no specific antidote to quetiapine. In cases of severe intoxication, the possibility of multiple drug involvement should be considered, and intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.
Close medical supervision and monitoring should be continued until the patient recovers.