Bacterial meningitis, Septicaemia
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 8,000-14,000 mg daily or 150-200 mg/kg daily in divided doses 3-4 hourly. May give initial treatment via slow IV inj for at least 3 days and continued with deep IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Neonate:
Doses are administered via slow IV inj over 3-5 minutes (for ≤500 mg doses) or 10-15 minutes (for >500 mg doses), IV infusion over ≥20 minutes, or via deep IM inj. Treatment duration depends on the pathogen and patient's clinical response. Dosage recommendations may vary among local guidelines (refer to specific country guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Neonate:
Gestational Age | Postnatal Age | Dosage |
≤34 weeks | ≤7 days | 50 mg/kg 12 hourly. |
8-<28 days | 75 mg/kg 12 hourly. | |
>34 weeks | ≤28 days | 50 mg/kg 8 hourly. |
Intramuscular, Intravenous
Endocarditis, Intra-abdominal infections, Peritonitis, Respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intramuscular, Intravenous
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intramuscular, Intravenous
Susceptible infections
Neonate: Preterm and term neonates
Alternative dosing recommendation:
Doses are administered via slow IV inj over 3-5 minutes (for ≤500 mg doses) or 10-15 minutes (for >500 mg doses), IV infusion over ≥20 minutes, or via deep IM inj. Treatment duration depends on the pathogen and patient's clinical response. Dosage recommendations may vary among local guidelines (refer to specific country guidelines).
Gestational Age | Postnatal Age | Dosage |
≤34 weeks | ≤7 days | 50 mg/kg 12 hourly. |
8-<28 days | 75 mg/kg 12 hourly. | |
>34 weeks | ≤28 days | 50 mg/kg 8 hourly. |
Alternative dosing recommendation:
Body Weight | Postnatal Age | Dosage |
≤2 kg | ≤7 days | 50 mg/kg 12 hourly. |
8-28 days | 75 mg/kg 12 hourly. | |
>2 kg | ≤28 days | 50 mg/kg 8 hourly. |
Intramuscular, Intravenous
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly; via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intravenous
Group B streptococcal meningitis
Neonate:
Doses are administered via slow IV inj over 3-5 minutes (for ≤500 mg doses) or 10-15 minutes (for >500 mg doses), or IV infusion over ≥20 minutes. Treatment duration: 14 days (for uncomplicated cases); longer duration may be required for prolonged or complicated courses. Dosage recommendations may vary among local guidelines (refer to specific country guidelines).
Postnatal Age | Dosage |
≤7 days | 100 mg/kg 8 hourly. |
>7 days | 75 mg/kg 6 hourly. |
Oral
Lower respiratory tract infections, Upper respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 250-1,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500 mg 6 or 8 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500-750 mg tid to 4 times daily. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Gonorrhoea
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. In combination with probenecid: 2,000 mg as a single dose; repeated doses are recommended in females. Consideration must be given to local treatment guidelines.
Child: Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Paratyphoid fever, Typhoid fever
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 1,000-2,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).