Discontinue use at the first appearance of skin rash, mucosal lesions or any other sign of hypersensitivity; possible serious skin reactions including exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis. Not recommended for patients w/ rare hereditary problems of galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption. GI bleeding, ulceration or perforation. Risk of serious CV thrombotic events (including MI & stroke). Monitor blood count; patients w/ defects of haemostasis. Asthma, seasonal allergic rhinitis, swelling of the nasal mucosa (ie, nasal polyps), COPD or chronic resp tract infections (especially if linked to allergic rhinitis-like symptoms), reactions on NSAIDs like asthma exacerbations (analgesics/analgesics-asthma intolerance), Quincke's edema or urticaria. May mask the signs & symptoms of infection. Concomitant use w/ systemic NSAIDs including cyclooxygenase-2 selective inhibitors. Regularly monitor hepatic function during prolonged treatment; discontinue use if abnormal liver function tests persist or worsen, if clinical signs or symptoms consistent w/ liver disease develop or if other manifestations (eg, eosinophilia, rash) occurs. Hepatic porphyria. Impaired cardiac or renal functions, history of HTN. Mild to moderate renal & hepatic impairment. Pregnancy (1st & 2nd trimesters). Not to be administered during breast feeding. Elderly ≥65 yr.
Sign Out
