Zyprexa

Olanzapine

Adults: Acute & maintenance treatment of schizophrenia & other psychoses where +ve &/or -ve symptoms are prominent. Alleviates secondary affective symptoms commonly associated w/ schizophrenia & related disorders. Monotherapy or in combination w/ lithium or valproate for acute manic or mixed episodes in bipolar disorder w/ or w/o psychotic features & w/ or w/o a rapid cycling course. Prevention of recurrence in patients w/ bipolar mania. Adolescents 13-17 yr: Acute treatment of schizophrenia. Acute manic & mixed episodes associated w/ bipolar disorder.

Adult Schizophrenia & related disorders Initially 10 mg once daily. Acute mania associated w/ bipolar disorder 15 mg once daily as monotherapy or 10 mg once daily in combination therapy w/ lithium or valproate. Preventing recurrence in bipolar disorder Initially 10 mg once daily. Patient w/ manic episode Continue therapy for preventing recurrence at the same dose. Patient w/ new manic, mixed, or depressive episode Continue treatment (w/ dose optimization as needed) w/ supplementary therapy to treat mood symptoms. Dose range during treatment for schizophrenia, manic episode & recurrence prevention in bipolar disorder: 5-20 mg daily. Increase in dose should generally occur at intervals of not <24 hr. Adolescent 13-17 yr Schizophrenia & acute manic or mixed episodes associated w/ bipolar disorder Initially 2.5 or 5 mg once daily. Adjust dose in increments/decrements of 2.5 mg or 5 mg when necessary. Dose range: 2.5-20 mg daily. Elderly, severe renal or moderate hepatic impairment Initially 5 mg daily.

May be taken with or without food.

Hypersensitivity.

Discontinue use if clinical manifestation of NMS or the presence of unexplained high fever w/o clinical manifestation of NMS; DRESS is suspected. Dose reduction or drug discontinuation if signs or symptoms of tardive dyskinesia appear. Patients w/ elevated ALT &/or AST, signs & symptoms of hepatic impairment, preexisting conditions associated w/ limited hepatic functional reserve, & those treated w/ potentially hepatotoxic drugs; prostatic hypertrophy, paralytic ileus, narrow angle glaucoma or related conditions. Hyperglycemia, diabetes, exacerbation of preexisting diabetes, ketoacidosis & diabetic coma; lipid alterations; cardiac death; cerebrovascular adverse events (eg, stroke, transient ischemic attack). History of seizures or are subject to factors which may lower the seizure threshold. Concomitant use w/ levodopa & dopamine agonists. Combination w/ other centrally acting drugs including alcohol. Galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Pregnancy. Not to be used during lactation. Childn <13 yr. Elderly patients w/ dementia-related psychosis.

Wt gain (≥7% of baseline bodywt); orthostatic hypotension; somnolence; total cholesterol (fasting borderline to high - ≥200 mg/dL & <240 mg/dL to ≥240 mg/dL), triglycerides (fasting borderline to high - ≥150 mg/dL & <200 mg/dL to ≥200 mg/dL), increased prolactin, glucose (fasting borderline to high - ≥100 mg/dL & <126 mg/dL to ≥126 mg/dL). Asthenia, pyrexia, wt gain (≥15% of baseline bodywt), fatigue; constipation, dry mouth, increased appetite; peripheral edema; arthralgia; akathisia, dizziness; increased ALT/SGPT, AST/SGOT, & alkaline phosphatase, total cholesterol (fasting normal to high - <200 mg/dL to ≥ 240 mg/dL), triglycerides (fasting normal to high - <150 mg/dL to ≥200 mg/dL); glucose (fasting normal to high - <100 mg/dL to ≥126 mg/dL), glycosuria, high γ-glutamyltransferase & uric acid; eosinophilia, leukopenia including neutropenia.

May antagonize effects of levodopa & dopamine agonists. Increased clearance by smoking, or w/ carbamazepine. Decreased clearance w/ potent CYP1A2 inhibitors & fluvoxamine. Additive pharmacological effects (eg, increased sedation) w/ ethanol. Mean increase in max conc & decrease clearance w/ fluoxetine. Reduced oral bioavailability w/ activated charcoal.

Antipsychotics

N05AH03 - olanzapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics

Rx