Tab Adult Treatment of herpes simplex 200 mg 5 times daily at approx every 4 hr intervals (omit night time dose) for 5 days.
Severely immunocompromised patient (eg, after marrow transplant) or those w/ impaired gut absorption Double the dose to 400 mg or alternatively, IV may be considered.
Suppression of herpes simplex infections Immunocompetent patient 200 mg qid at approx every 6-hr intervals or 400 mg bid at approx every 12-hr intervals. May titrate dose to 200 mg tid at approx every 8-hr intervals or 200 mg bid at approx every 12-hr intervals. Periodically interrupt therapy at 6-12 mth intervals.
Prophylaxis of herpes simplex in immunocompromised patient 200 mg qid at approx every 6-hr intervals.
Severely immunocompromised patient (eg, after marrow transplant) or those w/ impaired gut absorption Double the dose to 400 mg qid.
Treatment of varicella & herpes zoster 800 mg 5 times daily at approx every 4-hr intervals (omit nighttime dose) for 7 days.
Severely immunocompromised patient Consider IV dosing.
Management of severely immunocompromised patient 800 mg qid at approx every 60-hr intervals.
Childn Treatment & prophylaxis of herpes simplex in immunocompromised patient ≥2 yr Adult dose;
<2 yr ½ the adult dose.
Treatment of varicella Childn ≥6 yr 800 mg qid,
2-6 yr 400 mg qid,
<2 yr 200 mg qid or 20 mg/kg for 5 days. Max: 800 mg qid.
Powd for inj Adult Herpes simplex (except herpes encephalitis), varicella or herpes zoster 5 mg/kg every 8 hr.
Herpes encephalitis & immunocompromised patient w/ varicella zoster 10 mg/kg every 8 hr.
Prophylaxis of herpes simplex in immunocompromised patient Adult dose for herpes simplex.
Infant & childn ≥3 mth Herpes simplex (except herpes encephalitis) or varicella zoster 250 mg/m
2 BSA every 8 hr.
Immunocompromised patient w/ varicella zoster infections or herpes encephalitis 500 mg/m
2 every 8 hr.
Neonate Herpes simplex 10 mg/kg every 8 hr.
Known or suspected herpes 20 mg/kg every 8 hr for 21 days for disseminated & CNS disease or 14 days for skin & mucous membranes.