Adult 1-2 tab/day in 1-3 divided doses, gradually increased every 1-2 wk up to 2-4 tab/day in 1-3 divided doses. Max: 600 mg/day. Childn >6 yr 2-4 mg/kg/day in 1-3 divided doses, gradually increased every 1-2 wk up to 4-8 mg/kg/day in 1-3 divided doses. Max: 12 mg/kg/day.
Severe hepatic dysfunction or measure serum bicarbonate if signs & symptoms of those w/ anamnesis. Abrupt discontinuance of the administration may cause status epilepticus. Elderly & debilitated. Perform hepatic & renal function tests & blood exam regularly. Increased body temp particularly in ped patients. Suicidal ideation & behavior. Keep patient hydrated & out of high temp environment. Measure serum bicarbonate if signs or symptoms of metabolic acidosis occurs. Consider reducing or discontinuing treatment if metabolic acidosis develops & persists. Discontinue treatment if unexplained rash develops. Patients w/ risk factors of nephrolithiasis. Assess markers of muscle damage including serum creatine phosphokinase & aldolase levels. Monitor pancreatic lipase & amylase levels. Abnormality of Ig eg, IgA & IgG may occur. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn. Elderly.
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