Zithromax

Zithromax

azithromycin

Manufacturer:

Pfizer

Distributor:

Zuellig
Concise Prescribing Info
Contents
Azithromycin dihydrate
Indications/Uses
Infections caused by susceptible organisms in upper resp (including sinusitis & pharyngitis/tonsillitis) & lower resp (including bronchitis & pneumonia) tract, skin & soft tissue infections, acute otitis media. Uncomplicated genital infections due to Chlamydia trachomatis, chancroid due to Haemophilus ducreyi & uncomplicated genital infection due to non-multiresistant Neisseria gonorrhoeae; concurrent infection w/ Treponema pallidum should be excluded. Alone or in combination w/ rifabutin for prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection. In combination w/ ethambutol for the treatment of disseminated MAC (DMAC) infection in patients w/ advanced HIV infection. Inj: Community acquired pneumonia (CAP) caused by Legionella pneumophila & pelvic inflammatory diseases (PID) caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis in patients who require initial IV therapy.
Dosage/Direction for Use
Tab/Susp Adult Treatment of STD caused by Chlamydia trachomatis, Haemophilus ducreyi 1,000 mg as a single dose. Susceptible Neisseria gonorrhoeae 1,000 mg or 2,000 mg in combination w/ ceftriaxone 250 mg or 500 mg. Prophylaxis against MAC infection in patient w/ HIV 1,200 mg once/wk. DMAC infection in patient w/ advanced HIV 600 mg once daily. Susp Strep pharyngitis 3-day regimen: Childn >45 kg Adult dose, 36-45 kg 400 mg once daily on days 1-3, 26-35 kg 300 mg once daily on days 1-3, 15-25 kg 200 mg once daily on days 1-3, <15 kg 10 mg/kg once daily on days 1-3. 5-day regimen: Childn >45 kg Adult dose, 36-45 kg 400 mg on day 1, then 200 mg once daily on days 2-5, 26-35 kg 300 mg on day 1, then 150 mg once daily on days 2-5, 15-25 kg 200 mg on day 1, then 100 mg once daily on days 2-5, <15 kg 10 mg/kg on day 1, then 5 mg/kg once daily on days 2-5. Inj Adult CAP 500 mg as a single dose by IV infusion for at least 2 days. PID 500 mg as a single dose by IV infusion for 1 or 2 days. All indications Adult 500 mg/day for 3 days or alternatively, given for 5 days w/ 500 mg on day 1, then 250 mg on days 2-5. Childn Total dose: 30 mg/kg given as single dose of 10 mg/kg daily for 3 days or over 5 days w/ single daily dose of 10 mg/kg on day 1 then 5 mg/kg on days 2-5. Max: 1,500 mg. Acute otitis media 30 mg/kg as a single dose. Strep pharyngitis 10 mg/kg as a single dose or 20 mg/kg for 3 days. Max: 500 mg daily.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic.
Special Precautions
Hypersensitivity. Hepatoxicity. Infantile hypertrophic pyloric stenosis. Ergotism. Superinfection. Clostridium difficile-associated diarrhea. QT interval prolongation. Fructose intolerance, glucose-galactose malabsorption or saccharase-isomaltase deficiency. Myasthenia gravis. Do not administer as IV bolus or IM inj. Severe renal impairment (GFR <10 mL/min). Pregnancy & lactation.
Adverse Reactions
Transient episodes of mild neutropenia; hearing impairment (including hearing loss, deafness &/or tinnitus); nausea, vomiting, diarrhea, loose stools, abdominal discomfort (pain/cramps) & flatulence; abnormal liver function; allergic reactions including rash & angioedema; local pain & inflammation at the site of infusion.
Drug Interactions
Reduced peak serum conc w/ antacids. Increased serum levels of digoxin & colchicine. Possibility of interaction w/ ergot derivatives. Increased the conc of phosphorylated zidovudine. Rhabdomyolysis w/ statins. Elevated Cmax & AUC w/ cyclosporin. Insignificant decrease in Cmax w/ fluconazole. Neutropenia w/ rifabutin.
MIMS Class
Macrolides
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Zithromax FC tab 250 mg
Packing/Price
6's
Form
Zithromax FC tab 500 mg
Packing/Price
3's
Form
Zithromax powd for inj 500 mg
Packing/Price
1's
Form
Zithromax powd for oral susp 200 mg/5 mL
Packing/Price
15 mL x 1's;22.5 mL x 1's
/philippines/image/info/zithromax powd for oral susp 200 mg-5 ml/200 mg-5 ml x  22-5 ml?id=585b1723-b1fb-41cc-95b8-a39b01214991
/philippines/image/info/zithromax powd for oral susp 200 mg-5 ml/200 mg-5 ml x 15 ml?id=fd9633ce-4c50-4fca-9344-a39b01214991
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