Tab Adult Most infections, UTI, mild to moderate lower resp tract infections (eg, bronchitis), pyelonephritis 250 mg bid.
More severe lower resp tract infections or pneumonia (if suspected) 500 mg bid.
Uncomplicated gonorrhea 1 g as single dose.
Adult & childn >12 yr Lyme disease 500 mg bid for 14 days. Sequential therapy:
Pneumonia 1.5 g tid or bid (IV or IM) for 48-72 hr, followed by 500 mg bid for 7-10 days.
Acute exacerbations of chronic bronchitis 750 mg tid or bid (IV or IM) for 48-72 hr, followed by 500 mg tid or bid for 5-10 days.
Childn Most infections 125 mg bid.
Otitis media or more severe infections 250 mg bid.
<12 yr Lyme disease 250 mg bid for 14 days.
Renal impairment CrCl ≥30 mL/min 125-500 mg bid;
10-29 mL/min Standard individual dose every 24 hr;
<10 mL/min Standard individual dose every 48 hr.
Inj Adult 750 mg tid by IM or IV.
More severe infections 1.5 g tid IV. May be increased 6 hrly if necessary; total daily dose 3-6 g.
Gonorrhea 1.5 g as single dose, given as 2 x 750 mg IM at different sites.
Meningitis 3 g IV 8 hrly.
Infant & childn 30-100 mg/kg/day 3-4 divided doses. 60 mg/kg/day is appropriate for most infections.
Meningitis 150-250 mg/kg/day in 3-4 divided doses.
Neonate 30-100 mg/kg/day as 2-3 divided doses.
Meningitis 100 mg/kg/day IV.
Surgical prophylaxis 1.5 g IV w/ induction of anesth for abdominal, pelvic & orthopedic operations; may be supplemented w/ two 750 mg IM doses 8 & 16 hr later.
Cardiac, pulmonary, esophageal & vascular operations 1.5 g IV w/ induction of anesth continuing w/ 750 mg IM tid for a further 24-48 hr.
Total joint replacement 1.5 g cefuroxime may be mixed dry w/ each pack of methyl methacrylate cement polymer before adding the liqd monomer.
Renal impairment CrCl 10-20 mL/min 750 mg every bid,
<10 mL/min 750 mg once daily.
Patient on hemodialysis 750 mg IV or IM at the end of each dialysis.
Patient w/ renal failure on continuous arteriovenous hemodialysis or high flux hemofiltration 750 mg bid.
Sign Out
