Patient w/ CrCl >50 mL/min Complicated intra-abdominal infections 1.5 g (1 g/500 mg) for 1 hr infusion every 8 hr for 4-14 days in conjunction w/ metronidazole 500 mg IV every 8 hr.
Complicated UTI including pyelonephritis 1.5 g (1 g/500 mg) for 1 hr infusion every 8 hr for 7 days.
Nosocomial pneumonia including ventilator-associated pneumonia 3 g (2 g/1 g) for 1 hr infusion every 8 hr for 8-14 days.
Complicated intra-abdominal infections & complicated UTI including pyelonephritis Renal impairment CrCl 30-50 mL/min 750 mg (500 mg/250 mg) IV every 8 hr,
15-29 mL/min 375 mg (250 mg/125 mg) IV every 8 hr.
End-stage renal disease on hemodialysis 750 mg (500 mg/250 mg) as single loading dose followed by 150 mg (100 mg/50 mg) maintenance dose every 8 hr for the remainder of the treatment period. Administer at the earliest possible time following completion of dialysis on hemodialysis days.
Nosocomial pneumonia including ventilator-associated pneumonia Renal impairment CrCl 30-50 mL/min 1.5 g (1 g/0.5 g) IV every 8 hr,
15-29 mL/min 750 mg (500 mg/250 mg) IV every 8 hr.
End-stage renal disease on hemodialysis 2.25 g (1.5 g/0.75 g) as single loading dose followed by 450 mg (300 mg/150 mg) maintenance dose every 8 hr for the remainder of the treatment period. Administer at the earliest possible time following completion of dialysis on hemodialysis days.
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