AdultPancreatic cancer (as single agent) 1,000 mg/m2 by 30 min IV infusion once wkly for up to 7 wk, followed by 1 wk rest period. Subsequent cycle should consist of once wkly infusion for 3 consecutive wk every 4 wk. Non-small cell lung cancer (as combination) 4-wk schedule: 1,000 mg/m2 by 30 min IV infusion on days 1, 8 & 15 of each 28-day cycle + cisplatin 100 mg/m2 IV on day 1 after gemcitabine infusion. 3-wk schedule: 1,250 mg/m2 by 30 min IV infusion on days 1 & 8 of each 21-day cycle + cisplatin 100 mg/m2 IV on day 1 after gemcitabine infusion.
Monitor complete blood count including differential & platelet, leukocyte & granulocyte count. Consider suspension or modification of therapy upon detection of marrow suppression. Prolonged infusion time beyond 60 min. Renal & hepatic impairment, pregnancy.
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