Minor early hemarthrosis, superficial muscle or soft tissue & oral bleeds 20-40 IU/dL. Repeat every 12-24 hr as necessary until resolved. Duration: At least 1 day, depending upon the severity of the hemorrhage.
Moderate hemorrhages into muscles, mild head trauma capitus, minor operations including tooth extraction, hemorrhages into the oral cavity 30-60 IU/dL. Repeat infusion every 12-24 hr for 3-4 days or until adequate hemostasis is achieved. For tooth extraction, a single infusion + oral antifibrinolytic therapy w/in 1 hr may be sufficient.
Major GI bleeding, intracranial, intra-abdominal or intrathoracic hemorrhages, fractures, major operations 60-100 IU/dL. Repeat infusion every 8-24 hr until threat is resolved or in the case of surgery, until adequate local hemostasis is achieved, then continue therapy for at least another 7 days.
Prophylaxis 30 ± 5 IU/kg given 3 times wkly.
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