Colon, colorectal & breast cancer 1,250 mg/m
2 bid (morning & evening) for 2 wk followed by a 1-wk rest period given as 3-wk cycles. In combination w/ docetaxel: 1,250 mg/m
2 bid for 2 wk followed by a 1-wk rest period + docetaxel 75 mg/m
2 as 1-hr IV infusion every 3 wk.
Adjuvant treatment in patient w/ Dukes' C colon cancer 1,250 mg/m
2 bid for 2 wk followed by a 1-wk rest period given as 3-wk cycles. Total: 8 cycles (24 wk). In combination w/ oxaliplatin: 1,000 mg/m
2 bid for 2 wk followed by a 1-wk rest period + oxaliplatin 130 mg/m
2 IV infusion over 2-hr on day 1 every 3 wk, as 3-wk cycles for 24 wk.
Advanced or colon gastric cancer 1,250 mg/m
2 bid (morning & evening) for 2 wk followed by 1-wk rest period given as 3-wk cycles.
Advanced gastric cancer in combination w/ platinum-based regimen 1st-line treatment: Initially 1,000 mg/m
2 bid for 14 days followed by a 7-day rest period or 625 mg/m
2 bid. In combination w/ cisplatin: 1,000 mg/m
2 bid for 2 wk followed by a 1-wk rest period + cisplatin 80 mg/m
2 as 2-hr IV infusion every 3 wk. In combination w/ cisplatin or epirubicin: 625 mg/m
2 bid for 3 wk + cisplatin 60 mg/m
2 as a 2-hr IV & epirubicin 50 mg/m
2 as IV bolus infusion every 3 wk.
Patient w/ moderate renal impairment (CrCl 30-50 mL/min at baseline) Reduce dose to 75% for a starting dose of 1,250 mg/m
2.
Elderly ≥60 yr Starting dose reduction to 75% (950 mg/m
2 bid).
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