Tab UTI 125 mg bid. Resp tract infection 250-500 mg bid. Uncomplicated gonorrhea 1 g as single dose. Childn >3 mth & infant 125 mg bid or 10 mg/kg bid. Max: 250 mg daily. Childn >2 yr Otitis media 250 mg bid or 15 mg/kg bid. Max: 500 mg daily. IV Adult Meningitis 3 g every 8 hr. Surgical prophylaxis 1.5 g prior to procedure. May be supplemented by 750 mg every 8 hr for up to 24-48 hr. Total joint replacement 1.5 g powd may be mixed w/ methyl methacrylate cement. IMGonorrhea 1.5 g as single dose, divided between 2 inj sites. IV/IMAdultRenal impairment CrCl 10-20 mL/min 750 mg bid, <10 mL/min 750 mg once daily.
Hypersensitivity to cefuroxime, cephalosporins or penicillins (history). Patients predisposed to allergic symptoms eg, bronchial asthma, rash, urticaria; systemically in poor condition, unable to take diet in parenteral. False +ve reaction for glucose in urine w/ Benedict's & Fehling's soln or Clinitest tab. +ve direct Coombs' test. Regular monitoring of hepatic or renal function, blood. Severe renal impairment. Pregnancy & lactation. Childn (mild to moderate hearing loss). Elderly.
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