May interfere w/ lab tests that are based on a biotin/streptavidin interaction; false -ve troponin test results in patients w/ MI taking biotin. Renal impairment. Not to be given in childn <12 yr.
Possible allergic reactions in individual intolerant to biotin, which can be exhibited as a chest pain, shortness of breath, urticaria, appearance of skin rash.
Decreased plasma levels conc w/ anticonvulsants. Reduced activity of biotinidase w/ valproic acid. May cause biotin deficiency w/ plenty use of raw eggs for 2-3 wk. Avoid high doses of pantothenic acid.
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