Initially 5-10 mg in the evening. Ischaemic heart disease Initially 20 mg, may be adjusted at interval of not <4 wk up to max 80 mg once daily in 3 divided doses of 20 mg, 20 mg & 40 mg evening dose. Patient taking cyclosporine, fibric acid derivatives or nicotinic acid & at risk of myopathy Max: 10 mg once daily.
History of liver disease &/or consume substantial quantities of alcohol. Patients w/ predisposing factors for myopathy eg, renal impairment, advanced age & inadequately treated hypothyroidism. Uncomplicated myalgia & myopathy. Discontinue use if markedly elevated CK levels occur or myopathy is diagnosed or suspected. Therapy should be temporarily w/held in any patient w/ an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (eg, sepsis, hypotension, dehydration, major surgery, trauma, severe metabolic endocrine & electrolyte disorder or uncontrolled seizures). Avoid combination therapy w/ gemfibrozil.
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