Used in conditions where inhibition of gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, GERD, PUD & Zollinger-Ellison syndrome.
Dyspepsia 20 mg daily for 2-4 wk. GERD 20 mg once daily for 4 wk followed by further 4-8 wk if not fully healed. Refractory esophagitis 40 mg daily. Maintenance: 20 mg once daily. Childn 0.7-1.4 mg/kg daily for 4-12 wk up to max of 40 mg for 4-12 wk. PUD 20 mg or 40 mg in severe cases for 4 wk (duodenal ulcer) & 8 wk (gastric ulcer). Maintenance: 20 mg once daily. NSAID-associated ulceration 20 mg daily. Zollinger-Ellison syndrome Initially 60 mg once daily. Prophylaxis of acid aspiration during general anesth 40 mg on the evening before the surgery & 40 mg 2-6 hr pre-op.
May alter the metabolism of other drugs metabolized by cytochrome P450 & isoenzyme CYP2C19. May prolong elimination of diazepam, phenytoin & warfarin. Reduce absorption ketoconazole & possibly itraconazole. Plasma conc of both drugs may be increased w/ voriconazole. Reduced exposure w/ atazanavir.
A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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