Dose range of Ezetimibe/Simvastatin:
Patient w/ primary or mixed hyperlipidemia 10/10-10/40 mg/day. Usual starting dose: 10/20 mg/day. Patients requiring larger reduction in LDL-C (>55%) may be started at 10/40 mg/day.
Patient w/ CHD Starting dose: 10/40 mg once daily in the evening.
Patient w/ HoFH Max daily dose: 10/40 mg in the evening.
Patient taking lomitapide Max dose: 10/40 mg/day.
Childn 10-17 yr Usual starting dose: 10/10 mg once daily in the evening. Dosing range: 10/10-10/40 mg/day.
Co-administration w/ fenofibrate 10/10 mg or 10/20 mg/day,
w/ bile sequestrant Take either ≥2 hr before or ≥4 hr after administration of a bile sequestrant,
w/ amiodarone, verapamil or diltiazem Max daily dose: 10/20 mg,
w/ amlodipine Max daily dose: 10/40 mg.
Patient w/ CKD & GFR approx <60 mL/min/1.73 m2 10/20 mg once daily in the evening.
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