Doses may be given by intermittent IV infusion over 30 min or by deep IM inj. Adult 1-2 g daily as a single dose or in 2 divided doses. Severe infections Up to 4 g daily. Gonorrhea 250 mg IM as a single dose. Surgical infection prophylaxis 1 g as a single dose 0.5-2 hr prior to surgery. Childn 50-75 mg/kg daily in 2 divided doses. Max: 2 g daily. Meningitis 100 mg/kg daily in 2 divided doses, sometimes w/ a loading dose of 75 mg/kg. Max: 4 g daily.
Hypersensitivity to ceftriaxone or cephalosporins. Hyperbilirubinemic neonates, particularly prematures. Neonates <28 days receiving Ca containing IV products.
History of penicillin allergy. Severe renal disorder; poor oral ingestion or parenteral nutrition patients; patients w/ gallbladder, biliary tract, liver or pancreatic disease. Superinfections may occur w/ prolonged or repeated therapy. Pregnancy. Avoid use during lactation. Elderly.
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