Ventolin

Salbutamol sulfate

Treatment or prevention of bronchospasm. Syr: Relief of bronchospasm in bronchial asthma of all types, chronic bronchitis & emphysema. Nebules: Routine management of chronic bronchospasm (unresponsive to conventional therapy) & treatment of acute severe asthma (status asthmaticus).

Syr Adult Usual effective dose: 10 mL tid or qid, may be gradually increased to 20 mL if adequate bronchodilation is not obtained. Childn >12 yr 5-10 mL tid or qid, 6-12 yr 5 mL tid or qid, 2-6 yr 2.5-5 mL tid or qid. Elderly or those unusually sensitive to β-adrenergic stimulant drug 5 mL tid or qid. Rotacap For inhalation w/ a Rotahaler. Relief of acute bronchospasm Adult 200 or 400 mcg. Childn 200 mcg. Prevention of exercise-induced bronchospasm Adult 400 mcg before exertion. Childn 200 mcg before exertion. Chronic therapy Adult 400 mcg tid or qid. Childn 200 mcg tid or qid. MDI Relief of acute bronchospasm Adult 100 or 200 mcg. Childn 100 mcg. May be increased to 200 mcg if required. Prevention of allergen or exercise-induced bronchospasm Adult 200 mcg before exertion. Childn 100 mcg before exertion. May be increased to 200 mcg if required. Chronic therapy Adult & childn Up to 200 mcg qid. Nebules Adult & childn Initially 2.5 mg by wet inhalation, may be increased to 5 mg & may be repeated qid. Severe airway obstruction Adult 40 mg daily w/ strict medical supervision.

Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.

Hypersensitivity. Not to be used to arrest uncomplicated premature labour or threatened abortion. Rotacap: Patients w/ severe milk-protein allergy who have history of salbutamol hypersensitivity.

Sudden & progressive deterioration in asthma control. Thyrotoxicosis. Potentially serious hypokalaemia may result from nebulised therapy; caution in acute severe asthma as effect may be potentiated by concomitant use w/ xanthine derivatives, steroids, diuretics & by hypoxia; monitor serum K levels. Paradoxical bronchospasm may occur in inhalation therapy. Pregnancy. Not recommended during lactation. Syr: Increased risk of dental caries in long-term treatment. Nebules: Risk of anoxia through hypoventilation. Transient hypoxaemia may occur. Must be used by inhalation, w/ a nebuliser & should be breathed through the mouth. Must not be inj or swallowed. Patients known to receive large doses of other sympathomimetic drugs. Concomitant use w/ nebulised anticholinergics (ipratropium Br). Avoid contact w/ eyes. Monitor for the development of elevated serum lactate & consequent metabolic acidosis. Infant <18 mth. Syr/Nebules: Induced reversible metabolic changes (eg, increased blood sugar levels) & ketoacidosis may develop in diabetic patient. Concurrent use w/ corticosteroids.

Tremor, headache, tachycardia. Syr: Palpitations, muscle cramps.

Not to be prescribed w/ non-selective β-blockers eg, propranolol.

Antiasthmatic & COPD Preparations

R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
R03CC02 - salbutamol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.

Rx