Initially Fe 1,500 mg (3 tab) daily, divided across meals of the day. Up or down titrate dose in increments of Fe 500 mg (1 tab) daily every 2-4 wk until an acceptable serum P level is reached. Max tolerated daily dose: Fe 3,000 mg (6 tab)/day.
Patients w/ recent history of peritonitis (w/in last 3 mth), significant gastric or hepatic disorders & major GI surgery; diabetes (1 tab is equiv to approx carbohydrates 1.4 g or 0.116 bread u). Discoloured (black) stool. Contains sucrose & starches (carbohydrates). May be harmful to the teeth. Not to be taken by patients w/ fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Earlier stages of renal impairment. Severe hepatic impairment. Pregnancy & lactation. Childn <18 yr.
Monitor clinical effect & adverse events on initiation or dose-adjustment of either Velphoro or concomitant medicinal product w/ narrow therapeutic window. Administer any medicinal product known to interact w/ Fe (eg, alendronate & doxycycline) or w/ potential to interact w/ Velphoro (eg, levothyroxine) at least 1 hr prior to or 2 hr after Velphoro.
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