Palliative treatment of carcinoma of the colon, rectum, breast, stomach & pancreas not amenable to surgery or irradiation. Adjunct to surgery for the treatment of various solid tumors.
IV inj 12 mg/kg to a max of 0.8-1 g daily for 3-4 days. If there is no evidence of toxicity, this may be followed after 1 day by 6 mg/kg on alternative days for 3 or 4 further doses. Alternative schedule: 15 mg/kg IV once a wk throughout the course. Course may be repeated after 4-6 wk or maintenance doses of 5-15 mg/kg daily up to a max of 1 g wkly. IV infusion 15 mg/kg daily. Max: 1 g infused in 500 mL of 0.9% NaCl or 5% glucose inj over 4 hr repeated on successive days until toxicity occurs or a total of 12-15 g has been given. Intra-arterial infusion 5-7.5 mg/kg daily (regional perfusion).
Dihydropyrimidine dehydrogenase deficiency. Severe hepatic impairment. Monitor hepatic function tests. Patients w/ severe surgical pus &/or a history of heart disease. Observe for severe enteritis & dehydration. Discontinue if severe abdominal pain or diarrhea occurs.
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