Increased plasma levels w/ cimetidine & lowered plasma levels w/ furosemide. Elimination rate may be increased w/ diclofenac & warfarin. Increased exposure w/ strong CYP3A4 inhibitors. Increased AUC & C
max w/ ketoconazole; paroxetine. Risk of enhanced hypotensive effect w/ drugs reducing BP including anaesth agents & other α
1-adrenoreceptor antagonists.