Syncope. Do not use in women, childn. EC tab: Potential risk of intraoperative floppy iris syndrome, patient w/ serious or life-threatening allergy w/ sulfa drugs. Closely monitor BP in patients receiving antihypertensives. Rule out prostate carcinoma prior to treatment. ER tab: Perform digital rectal exam & determination of prostate specific antigen (PSA) prior to & during treatment at regular intervals. Patients w/ orthostatic hypotension, severe hepatic & renal insufficiency (CrCl <10 mL/min). Discontinue use 1-2 wk prior to cataract surgery. Closely monitor BP & heart rate. Elderly.
Cimetidine may result in a moderate increase in plasma levels. Diclofenac or warfarin may increase elimination rate. Enhanced hypotensive effect when given concurrently w/ other α-adrenergic blockers, anesth agents, Ca channel & β-blockers. Antihypertensives, furosemide.
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