175 mg/m2 IV over 3 hr every 3 wk. Premed prior to Unitaxel: Oral dexamethasone 20 mg 12 & 6 hr before Unitaxel, diphenhydramine 50 mg IV 30-60 min & cimetidine 300 mg prior to Unitaxel or ranitidine 50 mg IV 30-60 min before Unitaxel.
View Unitaxel overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to paclitaxel or other drugs formulated in cremophor + EL (polyethoxylated castor oil); patients w/ severe baseline neutropenia (<1,500 cells/mm3). Pregnancy & lactation.
Monitor occurrence of myelotoxicity. Perform frequent peripheral blood cell count. Monitor vital signs during 1st hr of infusion. Monitor cardiac function in patients who develop serious conduction abnormalities.
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