Adult Initial dose: 100 mg tid or 300 mg/day as a single dose. If after a strict cholesterol diet the conc of cholesterol stays at >4 g/L, dose can be increased to 100 mg qid. Initial dose should be maintained until cholesterol level returns to normal. If cholesterol level is stabilized, 100 mg bid can be given provided that the cholesterol level is checked every 3 mth. If there is a new increase in the plasma cholesterol conc, 100 mg tid.
For the 1st yr therapy, serum transaminase should be monitored every 3 mth. Therapy should be discontinued if there is an increase in SGPT conc >100 u/L.
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