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The maximum tolerated dose in humans is unknown.
Nausea, vomiting, dizziness and confusion are likely symptoms of overdosage.
Bone marrow depression has been reported in acute trimethoprim overdosage.
In cases of known, suspected or accidental overdosage, stop therapy.
Dependent on the status of renal function, administration of fluids is recommended if urine output is low.
Both trimethoprim and active sulfamethoxazole are dialyzable by renal dialysis. Peritoneal dialysis is not effective.
