Triderm Overdosage

Symptoms: Excessive or prolonged use of topical corticosteroids can suppress pituitary-adrenal function, resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease.
Since application of ¹⁴C labeled clotrimazole to intact or diseased skin under occlusive dressing for six hours did not yield measurable quantities (lower detection limit 0.001 mcg/ml) of radioactive material in the sera of human subjects, overdosage by topical clotrimazole administration is highly improbable.
A single overdose of gentamicin would not be expected to produce symptoms. Excessive or prolonged use of topical gentamicin may lead to overgrowth of lesions by non-susceptible microorganisms.
Treatment: Appropriate symptomatic treatment is indicated. Acute hypercorticoid symptoms are usually reversible. Treat electrolyte imbalance, if necessary. In case of chronic toxicity, slow withdrawal of corticosteroids is advised.
If overgrowth by non-susceptible microorganisms occurs, stop treatment with Betamethasone/Clotrimazole/Gentamicin (TRIDERM) Ointment and institute appropriate therapy.