Adult 500 mcg IV daily for max 5 days. Childn 15 mcg/kg IV daily for 5 days or 2.5 mg/m2 IV over a 1 wk period. Adult & childn A 2nd course may be given after at least 3 wk if all signs of toxicity have disappeared.
Hepatic or renal impairment, bone marrow suppression, complicated infections. Do not administer IM or SC. Avoid extravasation, inhalation of dust or vapors or contact w/ skin & mucous membranes. Administration w/in 2 mth of irradiation. Discontinue treatment if stomatitis, diarrhea or severe hemopoietic depression occurs. Monitor renal, hepatic & bone marrow functions regularly. May interfere w/ bioassay procedures for the determination of antibacterial drug levels. Bleeding. Women of childbearing potential. Lactation. Childn.
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