Do not exceed the recommended dose. Avoid prolonged dosage interval. Not suitable as substitute in opioid-dependent patients. Convulsions may occur in patients susceptible to seizures or taking other drugs that lower seizure threshold especially SSRIs, TCAs, antipsychotics, centrally-acting analgesics or local anesth; increased risk when exceeded the recommended upper dose limit. Opioid-dependent patients or those w/ cranial trauma, prone to convulsive disorder, biliary tract disorders, in a state of shock, in an altered state of consciousness for unknown origin, w/ problems affecting the resp center/function, or w/ increased intracranial pressure. Potential to cause w/drawal symptoms. Cases of dependence & abuse may occur (rare). May affect ability to drive or operate machinery.
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