Acute alcohol or CNS-acting drug (eg, hypnotics, analgesics or psychotics) intoxication, severe resp depression, patients at risk of stupor due to head injuries/lesions, receiving MAOIs & w/ raised intracranial pressure.
Not indicated for minor pain. Patients w/ decreased resp reserve & should not be given during bronchial asthma attack or in heart failure secondary to chronic lung disease; cholangia, hypothyroidism, adrenocortical insufficiency, prostatic hypertrophy, shock or inflammatory or obstructive bowel disorders, myasthenia gravis. Delayed resp depression following epidural or intra-tracheal administration. Possibility of dependence cannot be excluded. Concomitant use of morphine. Debilitated & alcoholic patients. Hepatic & renal disorders. May impair ability to drive & operate machinery. Pregnancy & lactation. Childn & infant. Elderly.
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