Hypersensitivity to aspirin or other NSAIDs. Suspected or confirmed cerebrovascular bleeding or hemophilia, other bleeding problems eg coagulation or platelet function disorders. Active, recent or history of GI bleeding or recent GI perforation or active or history of peptic ulcer, ulceration colitis or other ulcerative GI disease. Aspirin-induced nasal polyps associated w/ bronchospasm or angioedema; anaphylaxis or history of other severe allergic reactions of cross-sensitivity. Moderate or severe renal impairment. History of asthma. Hypovolemia or dehydration. Should not be given post-op in patients w/ high risk of bleeding, pre-op as prophylactic analgesic & intraoperatively. Pregnancy, labor, delivery & lactation. Childn <16 yr.
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