Adult HTN Initially 80 mg or 160 once daily, in patients whose blood pressure is not adequately controlled may be increased to 320 mg, or may add diuretic. Max: 320 mg once daily.
Heart failure 40 mg bid. Up-titration to 80 mg to 160 mg bid should be done to the highest dose tolerated by patient. Consideration to reduce dose of concomitant diuretics. Max: 320 mg divided doses.
Post MI may initiate as early as 12 hr after MI. Initial dose 20 mg bid. Therapy should be titrated to 40 mg, 80 mg & 160 mg bid over the next few wk. Starting dose 40 mg divisible tablet. Target Max: 160 mg bid. 2 wk after treatment initiation 80 mg bid. Max: 160 mg bid.
Hypertensive adult patient w/ impaired glucose tolerance at CV risk 80 or 160 mg once daily. Starting 80 mg, up titration to 160 mg once daily as tolerated by patient.
Childn & adolescent 6-18 yr Initial dose 40 mg once daily for <35 kg of wt, & 80 mg once daily for ≥35 kg.
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