There were no systemic adverse effects following a single inhaled dose of up to 340 micrograms Tiotropium bromide in healthy volunteers. No relevant adverse effects, beyond dry mouth, were observed following a 7-day dosing of up to 170 micrograms Tiotropium bromide in healthy volunteers. However, high doses of Tiotropium bromide may lead to anticholinergic signs and symptoms, include fast heart rate, increased pressure in the eyes, unable to urinate, flushing, dry skin and mouth, altered mental status, dilated (widened) pupils, which are the dark center of the eyes. If an overdose is suspected, seek medical attention immediately.
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