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TNA-Peri

TNA-Peri

Manufacturer:

Otsuka (Philippines)

Distributor:

Zuellig

Marketer:

Otsuka (Philippines)
Concise Prescribing Info
Contents
Per 100 mL of compartment 1 Anhydrous glucose BP 15 g. Per 100 mL of compartment 2 L-isoleucine USP 0.51 g, L-leucine USP 0.89 g, L-lysine HCl USP 0.7 g, L-methionine USP 0.38 g, L-phenylalanine USP 0.51 g, L-threonine USP 0.41 g, L-tryptophan USP 0.18 g, L-valine USP 0.48 g, L-arginine USP 0.92 g, L-histidine USP 0.52 g, Glycine USP 0.79 g, L-alanine USP 1.37 g, L-proline USP 0.89 g, L-aspartic acid BP 0.13 g, L-asparagine H2O 0.372 g, L-cysteine HCl H2O USP 0.073 g, L-glutamic acid BP 0.46 g, L-ornithine HCl 0.32 g, L-Serine USP 0.24 g, L-tyrosine USP 0.03 g, Acetyltyrosine BP 0.123 g, L-malic acid 0.1 g, Na acetate 3H2O BP 0.395 g, K acetate USP 0.245 g, Na dihydrogen phosphate 2H2O BP 0.14 g. Per 100 mL of compartment 3 soybean oil USP 10 g, medium chain triglycerides BP 10 g, egg lecithin 1.2 g, glycerol 2.5 g
Indications/Uses
Parenteral nutrition for adults where oral or enteral route for nutrition is not available, not possible, not sufficient or contraindicated.
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Dosage/Direction for Use
Individualized dosage. Maintenance of body protein mass Nitrogen requirements: 0.1-0.15 g nitrogen/kg/day in the normal state & degree of catabolic stress. Moderate to high metabolic stress w/ or w/o malnutrition 0.15-0.3 g nitrogen/kg/day. Infusion rate: 1 mL/min through central or peripheral vein for 10-15 min. If no adverse reactions occur, the rest of the soln can be infused at 2-3 mL/min. Infusion period: 12-24 hr.
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Overdosage
View TNA-Peri overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to egg or soy protein. Severe hyperlipidemia, severe liver insufficiency, severe blood coagulation disorders, in born errors of amino acid metabolism, severe renal insufficiency w/o access to hemofiltration or dialysis, acute shock, hyperglycemia which requires > 6 u insulin/h, pathologically elevated serum levels of any of the included electrolytes. General contraindications to infusion therapy: Acute pulmonary HTN, hyperhydration, decompensated cardiac insufficiency & hypotonic dehydration, hemophagocytic syndrome, unstable conditions (eg, severe post-traumatic conditions, uncompensated diabetes, acute MI, metabolic acidosis, severe sepsis & hyperosmolar coma).
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Warnings
For additional cautionary notes to warn of the potential risk of using the medicine... Click to view TNA-Peri detailed prescribing information
Special Precautions
For single use only. Conditions w/ impaired lipid metabolism eg, in renal insufficiency, uncompensated DM, pancreatitis, impaired liver function, hypothyroidism (w/ hypertriglyceridemia) & sepsis; metabolic & lactic acidosis, insufficient cellular O2 supply & increased serum osmolarity; patients w/ a tendency towards electrolyte retention. Disturbances of electrolyte & fluid balance should be corrected before starting the infusion. Do not use if separation of fat emulsion is observed. Should not be given simultaneously w/ blood in the same infusion set due to the risk of pseudo agglutination. Increased risk of infection is associated w/ use of any central vein, strict aseptic precautions should be taken. Monitor serum glucose, electrolytes & osmolarity & fluid balance, acid-base status & liver enzyme tests (alkaline phosphatase, ALT, AST). Monitor blood cell count & coagulation when fat is given for a longer period. Malnourished patients. Pregnancy & lactation. Not suitable for use in newborns or infants <2 yr.
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Adverse Reactions
Hyperthermia, sweating, shivering, headache, dysponea. Temporary increased alkaline phosphatase, transaminase & bilirubin levels in long term parenteral nutrition (>6-8 wk). Thrombopenia (in childn). Thrombophlebitis.
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Drug Interactions
Some additives eg, electrolytes, trace elements, vit & drugs may be incompatible. Should not be administered w/, before or after an administration of blood through the same equipment due to possibility of pseudo agglutination.
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Caution For Usage
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Storage
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Description
View TNA-Peri description for details of the chemical structure and excipients (inactive components).
Action
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MIMS Class
Parenteral Nutritional Products
ATC Classification
V06DE - Amino acids/carbohydrates/minerals/vitamins, combinations ; Used as general nutrients.
Presentation/Packing
Form
TNA-Peri emulsion for infusion
Packing/Price
(triple chambered non-PVC bag) 1000 mL x 1's
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