Patients w/ hepatic impairment or biliary obstruction. Renal impairment. Do not initiate during pregnancy & stop immediately when pregnancy is diagnosed. Not recommended during breastfeeding.
Antihypertensive effects may be potentiated by drugs or other agents that lower BP. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics, or other drugs that can cause hyperkalaemia. Risk of renal impairment may be increased w/ NSAIDs particularly in those who are inadequately hydrated. Hypotensive effect may be attenuated w/ NSAIDs. Interactions may occur w/ drugs that affect cytochrome P450 isoenzymes. May increase serum conc of digoxin.
Sign Out
