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The antihypertensive effects of telmisartan may be potentiated by drugs or other agents that lower blood pressure. An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalaemia; telmisartan and potassium-sparing diuretics should not generally be given together. NSAIDs should be used with caution particularly in patients taking telmisartan as the risk of renal impairment may be increased particularly in those who are inadequately hydrated. Use of NSAIDs may also attenuate the hypotensive effect of telmisartan. Telmisartan and some other angiotensin II receptor antagonists are metabolized by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.
Telmisartan may increase serum concentrations of Digoxin but the interaction is probably not clinically significant.
