Reduced clearance in patients w/ biliary obstructive disorders or hepatic insufficiency. Oliguria &/or progressive azotemia in patients whose renal function depends on the renin-angiotensin-aldosterone system activity (eg, patients w/ severe CHF). Increased serum creatinine or BUN in patients w/ unilateral or bilateral renal artery stenosis. Closely monitor renal function. Not recommended w/ concomitant use of ramipril. Lactation. Childn.
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