Cap Individualized dosage. 50-100 mg every 4-6 hr. Max: 400 mg/day. Inj 50-100 mg IV every 4-6 hr over 2-3 min or by IV infusion. Post-op pain Initially 100 mg followed by 50 mg every 10-20 min if necessary. Max (including initial dose): 250 mg in the 1st hr. Doses are 50-100 mg every 4-6 hr to total daily dose of 600 mg. CrCl <30 mL/min & severe hepatic impairment Dosage interval should be increased to 12 hr. Max: 200 mg/day.
Renal or liver impairment. Avoid in severe renal impairment. Patients w/ history of epilepsy or those susceptible to seizures. Do not take during light planes of general anesth. May have lower potential for producing dependence than morphine.
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