History of penicillin hypersensitivity &/or to multiple allergens. Consider pseudomembranous colitis in patients who develop diarrhea or colitis. Perform periodic assessment of full blood count, organ system functions including hematopoietic, renal & hepatic function during prolonged therapy. Bleeding manifestation, neuromuscular excitability or convulsions. Possibility of emergence of resistant organisms that may cause superinfection. Cystic fibrosis. Patients on controlled Na diet & w/ low K reserves. Repeated use of lignocaine as diluent. Not for the treatment of meningitis & brain abscess. High doses may mask the symptoms of syphilis. False +ve reaction in urine glucose tests using copper-reduction method, in Bio-Rad Laboratories Platelia Aspergillus EIA test & in Coombs' test. Renal impairment. Pregnancy & lactation. Childn <2 yr.
Prolonged t½ & lower renal clearance w/ probenecid. Reduced elimination t½ & increased total body clearance of tobramycin in patients w/ severe renal dysfunction. Prolonged neuromuscular blockade of vecuronium. Reduced excretion of methotrexate. Physical incompatibility w/ another antibiotic especially aminoglycosides. Test & monitor regularly coagulation parameters during simultaneous administration of high-dose heparin, other antibiotics especially aminoglycosides, oral anticoagulants & other drugs that affect blood coagulation system &/or thrombocyte function.
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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