Tazocin Description

Piperacillin/tazobactam is an injectable antibacterial combination consisting of the semisynthetic antibiotic piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.
Piperacillin sodium is derived from D(-)-a-aminobenzylpenicillin. The chemical name of piperacillin sodium is sodium (2S, 5R, 6R)-6-[(R)-2-(4-ethyl--dioxo-1-piperazinecarboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylate. Piperacillin sodium is a white, crystalline powder. It is freely soluble in water, alcohol, and methyl alcohol but is practically insoluble in ethyl acetate.
Tazobactam sodium is a derivative of the penicillin nucleus. Chemically, tazobactam is a penicillanic acid sulfone. Its chemical name is sodium(2S-,3S-,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate,4,4-dioxide. Tazobactam sodium is a white to pale yellow non-hydroscopic crystalline powder.
2.25 g vial: Each single-dose vial contains piperacillin sodium equivalent to 2 g of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. It also contains 72 mg citric acid monohydrate and 0.5 mg of edetate disodium (dihydrate) (EDTA) per vial.
4.5 g vial: Each single-dose vial contains piperacillin sodium equivalent to 4 g of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam. It also contains 144 mg citric acid monohydrate and 1 mg of edetate disodium (dihydrate) (EDTA) per vial.