Dose can be given by deep IM inj, slow IV inj over 3-5 min or IV infusion over 30 min.
Adult 1-6 g daily in divided doses every 8-12 hr.
Cystic fibrosis w/ pseudomonal lung infections 100-150 mg/kg daily in 3 divided doses.
Cystic fibrosis w/ normal renal function Up to 9 g/day; >1 g single dose should be given IV.
Childn 30-100 mg/kg daily in 2-3 divided doses.
Severely ill childn 150 mg/kg daily. Max: 6 g daily in 3 divided doses.
Neonate & infant ≤2 mth 25-60 mg/kg daily in 2 divided doses.
Elderly Max: 3 g daily.
Renal impairment CrCl 31-50 mL/min 1 g every 12 hr,
16-30 mL/min 1 g every 24 hr,
16-6 mL/min 0.5 g every 24 hr,
<5 mL/min 0.5 g every 48 hr.
Patient undergoing peritoneal dialysis Loading dose: 1 g, followed by 500 mg every 24 hr.
Patients on hemodialysis Repeat appropriate maintenance dose after each dialysis period.
Prophylaxis in prostatic surgery 1 g at induction of anesth, repeat if necessary.
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