Hypersensitivity. Active thromboembolic disease (eg, pulmonary embolism, DVT), history of venous or arterial thrombosis (including retinal vein or artery occlusion), disseminated intravascular coagulation, fibrinolytic conditions after consumption coagulopathy, history of convulsion. Concomitant use w/ hormonal contraceptives. Severe renal impairment.