Synflorix

Synflorix

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
Concise Prescribing Info
Contents
Pneumococcal polysaccharide, adsorbed non-typeable Haemophilus influenzae (NTHi) protein D conjugate vaccine
Indications/Uses
Active immunization in infants & childn 6 wk-5 yr against disease caused by Strep pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F & cross-reactive serotype 19A (including sepsis, meningitis, pneumonia, bacteraemia & acute otitis media).
Dosage/Direction for Use
IM Infant 6 wk-6 mth 3-dose primary series: 3 primary doses of 0.5 mL each w/ an interval of at least 1 mth between doses & a booster dose at least 6 mth after the last primary dose. 1st dose may be given as early as 6 wk of age & the booster dose from the age of 9 mth onwards. 2-dose primary series: 2 primary doses of 0.5 mL each given 2 mth apart & a booster dose at least 6 mth after the last primary dose. 1st dose may be given as early as 6 wk of age & the booster dose from the age of 9 mth onwards. Pre-term infant born at least 27 wk of gestation 3 primary doses of 0.5 mL each w/ the 1st dose given at 2 mth of age, w/ 1-mth interval between doses. Booster dose Administer at least 6 mth after the last primary dose. Previously unvaccinated childn 12 mth to 5 yr 2 doses of 0.5 mL w/ at least 2-mth interval between doses. Infant 7-11 mth 2 doses of 0.5 mL w/ at least 1-mth interval between doses. Administer 3rd dose in the 2nd yr of life w/ at least 2-mth interval.
Contraindications
Special Precautions
Rare anaphylactic event following vaccination. Postpone vaccination in patients w/ acute severe febrile illness. Do not administer intravascularly or intradermally. Syncope (fainting) as a psychogenic response. Thrombocytopenia or any coagulation disorder. Not a substitute for routine immunization w/ diphtheria, tetanus or HIB vaccines. Childn w/ impaired immune responsiveness, whether due to the use of immunosuppressive therapy, genetic defect, HIV infection; high-risk for pneumococcal disease (eg, SCD, asplenia, HIV infection, chronic illness or those who have other immunocompromising conditions). Prophylactic administration of antipyretics. Monitor resp for 48-72 hr in very premature infants (≤28 wk of gestation) particularly those w/ previous history of resp immaturity.
Adverse Reactions
Appetite loss, irritability, drowsiness, pain, redness, swelling at inj site, fever ≥38°C rectally (age <2 yr). Inj site reactions like inj site induration, fever >39°C rectally (age <2 yr); fever ≥38°C rectally (age 2-5 yr) after booster vaccination of primary series &/or catch-up vaccination.
Drug Interactions
Inactivated polio virus type 2 & MenACWY-TT vaccine. Enhancement of antibody response to Hib-TT conjugate, diphtheria & tetanus antigens. Immunosuppressants.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07AL52 - pneumococcus purified polysaccharides antigen and haemophilus influenzae, conjugated ; Belongs to the class of pneumococcal vaccines.
Presentation/Packing
Form
Synflorix vaccine inj
Packing/Price
(pre-filled syringe w/ plunger stopper) 0.5 mL x 1's;0.5 mL x 10 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in