Infections; thrombotic microangiopathy, anemia, thrombocytopenia, neutropenia, leukopenia, lymphophenia; hypersensitivity, angioedema; hyperthyroidism, hypothyroidism, thyroiditis; dehydration, hypoglycemia, tumor lysis syndrome, decreased appetite; insomnia, depression; cerebral hemorrhage, CVA, cerebral infarction, transient ischemic attack, posterior reversible encephalopathy syndrome, headache, dizziness, paresthesia, ageusia, dysgeusia; periorbital & eyelid edema, increased lacrimation; myocardial ischemia, MI, cardiac failure, cardiomyopathy, left ventricular failure, Torsade de pointes, congestive cardiac failure; aneurysms & artery dissections, tumor hemorrhage, HTN, DVT; pulmonary embolism, dyspnea, hemoptysis, pleural effusion, epistaxis, oropharyngeal pain; GI hemorrhage/perforation, pancreatitis, esophagitis, abdominal distension/pain, diarrhea, vomiting, nausea, GERD, dyspepsia, stomatitis, constipation, oral pain, glossodynia, gingival bleeding, dry mouth, flatulence; hepatic failure, cholecystitis; SJS, erythema multiforme, pyoderma gangrenosum, dermatitis exfoliative, skin reaction/lesion, rash, erythema, pruritus, skin exfoliation, palmar-plantar erythrodysaesthesia syndrome, blister, skin discolouration, hair color changes, alopecia, nail disorder, dry skin; fistula, rhabdomyolysis, jaw osteonecrosis, myopathy, arthralgia, myalgia, pain in extremity; renal failure, nephrotic syndrome, renal impairment, urinary tract hemorrhage, urinary tract hemorrhage, proteinuria, chromaturia; fatigue, mucosal inflammation, edema, pyrexia, chills, flu-like illness; decreased ejection fraction, Hb, platelet count, WBC, & wt; increased lipase, blood uric acid, amylase, blood TSH, & blood creatine phosphokinase.