Headache and drowsiness, gastrointestinal disturbances including cramps, and diarrhea; Ataxia, mental confusion and skin rashes; Gynecomastia (not uncommon) and in rare cases of breast enlargement may persist; Endocrine disorders including hirsutism, deepening of the voice, menstrual irregularities and impotence; transient increase in blood-urea-nitrogen concentrations may occur; mild acidosis; hyponatremia; Breast cancer, agranulocytosis, effects on electrolyte imbalance; increase serum-cholesterol concentrations; lichen-planus-like skin eruptions and chloasma-like pigmentation on the face.