Sevorane Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Sevoflurane

Indications/Uses

Induction & maintenance of general anesth in adult & childn for inpatient & outpatient surgery.

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Dosage/Direction for Use

Induction: Individualized dosage. Adult & childn Inspired conc of up to 8% in <2 min w/ O₂ or O₂-nitrous oxide mixt. Maintenance: 0.5-3% w/ or w/o concomitant use of nitrous oxide.

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Overdosage

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Contraindications

Hypersensitivity to other halogenated anesth. Known or suspected genetic susceptibility to malignant hyperthermia.

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Special Precautions

Latent/overt neuromuscular disease particularly Duchenne muscular dystrophy. QT prolongation, ventricular arrhythmia (ped w/ Pompe's disease). Malignant hyperthermia & (rarely) seizure; patients w/ mitochondrial disorders. Maintain hemodynamic stability in CAD patients; dessicated CO₂ absorbents; renal impairment; risk for ICP elevations. May increase potential for hepatic injury. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn & infants. Elderly.

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Adverse Reactions

Dose-dependent cardioresp depression, nausea, vomiting, hypotension, (ped) agitation & cough, (elderly) bradycardia.

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Drug Interactions

Nitrous oxide, nondepolarizing muscle relaxants (pancuronium, vecuronium or atracurium). May increase metabolism & activity of CYP450 eg, INH & alcohol.

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Storage

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Description

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Action

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MIMS Class

Anaesthetics - Local & General

ATC Classification

N01AB08 - sevoflurane ; Belongs to the class of halogenated hydrocarbons. Used as general anesthetics.

Regulatory Classification

Presentation/Packing

Form

Sevorane inhalation vapour liqd

Packing/Price

250 mL x 1's

Sevorane

sevoflurane

Manufacturer:

Abbvie

Distributor:

Zuellig